What is Multibiodose?

Blood samples © Bundesamt fr Strahlenschutz (BfS) Preparation of a slide for cytogenetics. © Bundesamt fr Strahlenschutz (BfS)

Multi-disciplinary biodosimetric tools to manage high scale radiological casualties (MULTIBIODOSE) - Capability project funded within the 7th EU Framework Programme under Theme 10 - SECURITY.

The MULTIBIODOSE project was launched on May 1st 2010, and it is planned to continue until April 2013.

The purpose of this multi-disciplinary collaborative project is to analyse a variety of biodosimetric tools and adapt them to different mass casualty scenarios. It is envisaged that the project will result in an establishment of a biodosimetric network that is fully functional and ready to respond in case of a mass casualty.

In the event of a large scale radiological emergency, biological dosimetry is an essential tool that can provide timely assessment of radiation exposure to the general population and enable the identification of those exposed who should receive medical treatment. A number of biodosimetric tools are potentially available, but they must be adapted and tested for a large-scale emergency scenario. These methods differ in their specificity and sensitivity to radiation, the stability of signal and speed of performance. A large scale radiological emergency can take different forms. Based on the emergency scenario, different biodosimetric tools should be applied so that the dosimetric information can be made available with optimal speed and precision.

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Cell in metaphase with dicentric chromosome - Gold standard method for biological dosimetry. © Bundesamt fr Strahlenschutz (BfS)
Metaphase finder with software for chromosomal aberration analysis. © Bundesamt fr Strahlenschutz (BfS)

Micronucleus assay  picture from the analysis in the automated assay. © A. Vral, Universiteit Gent Visualisation of gamma-H2AX in cells by staining with fluorescence dye DAPI. © Health Protection Agency (HPA)

Electron Paramagnetic Resonance instrumentation. © F. Trompier, Institut de Radioprotection et de Sret Nuclaire (IRSN) Electron Paramagnetic Resonance (EPR) signal. © A. Wojcik, Stockholm University

Serum Protein Assay (SPA)  protein profile obtained by two-dimensional gel electrophoresis. © S. Haghdoost, Stockholm University Optical Stimulated Luminescence (OSL) reader. © Institut de Radioprotection et de Sret Nuclaire (IRSN)

CABAS  Chromosomal aberrations calculation software. ©  A. Wojcik, Stockholm University